03. December 2020

Angelmann and Prader-Willi syndromes are two distinct genetic conditions with different symptoms, both caused by loss of a part of chromosome 15. Children who inherit one copy of this faulty chromosome develop either Angelmann or Prader-Willi syndrome, despite having a normal copy of the chromosome from their other parent. So how does the same mutation (loss of part of chromosome 15) lead to these two different conditions? The answer lies in the discovery that this particular piece of...